Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-[2-hydroxy-6-(3-hydroxyphenyl)-1-naphthyl]-N-methylacrylamide | 58% inhibition at 0.001 mM | Homo sapiens | |
(2E)-3-[2-hydroxy-6-(3-hydroxyphenyl)-1-naphthyl]-N-phenylacrylamide | 60% inhibition at 0.001 mM | Homo sapiens | |
1-bromo-6-(3-hydroxyphenyl)-2-naphthol | 88% inhibition at 0.001 mM | Homo sapiens | |
2-hydroxy-6-(3-hydroxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-1-naphthamide | 73% inhibition at 0.001 mM | Homo sapiens | |
2-hydroxy-6-(3-hydroxyphenyl)-N-methyl-1-naphthamide | 76% inhibition at 0.001 mM | Homo sapiens | |
2-hydroxy-6-(3-hydroxyphenyl)-N-phenyl-1-naphthamide | 80% inhibition at 0.001 mM | Homo sapiens | |
2-hydroxy-N,6-bis(3-hydroxyphenyl)-1-naphthamide | 70% inhibition at 0.001 mM | Homo sapiens | |
3-hydroxy-7-(3-hydroxyphenyl)-1-naphthonitrile | 99% inhibition at 0.001 mM | Homo sapiens | |
3-hydroxy-7-(3-hydroxyphenyl)-N-methyl-2-naphthamide | 18% inhibition at 0.001 mM | Homo sapiens | |
3-hydroxy-7-(3-hydroxyphenyl)-N-phenyl-2-naphthamide | 62% inhibition at 0.001 mM | Homo sapiens | |
3-[2-hydroxy-6-(3-hydroxyphenyl)-1-naphthyl]-N-methylpropanamide | 80% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-((4-methylphenyl)sulfonyl)-2-naphthol | 75% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-(morpholin-4-ylcarbonyl)-2-naphthol | 62% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-(phenylsulfonyl)-2-naphthol | 33% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-(piperazin-1-ylcarbonyl)-2-naphthol | 45% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-(piperidin-1-ylcarbonyl)-2-naphthol | 73% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-1-phenyl-2-naphthol | 89% inhibition at 0.001 mM | Homo sapiens | |
6-(3-hydroxyphenyl)-2-naphthol | 94% inhibition at 0.001 mM | Homo sapiens | |
7-hydroxy-3-(3-hydroxyphenyl)-1-naphthonitrile | 53% inhibition at 0.001 mM | Homo sapiens | |
additional information | not inhibited by 2-hydroxy-6-(3-hydroxyphenyl)-N-pyridin-2-yl-1-naphthamide and 2-hydroxy-6-(3-hydroxyphenyl)-N-(pyrimidin-2-yl)-1-naphthamide | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH + H+ | - |
? | |
estradiol-17beta + NADP+ | - |
Homo sapiens | estrone + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
in 20 mM KH2PO4, pH 7.4, at 25°C | Homo sapiens | 6-(3-hydroxyphenyl)-1-phenyl-2-naphthol | |
0.00004 | - |
in 20 mM KH2PO4, pH 7.4, at 25°C | Homo sapiens | 1-bromo-6-(3-hydroxyphenyl)-2-naphthol | |
0.000116 | - |
in 20 mM KH2PO4, pH 7.4, at 25°C | Homo sapiens | 6-(3-hydroxyphenyl)-2-naphthol |